Leiden Longevity Study
For the Leiden Longevity Study, long-lived siblings of European descent were recruited together with their offspring and the partners of this offspring between 2002 and 2006. Families were recruited if at least two long-lived siblings were alive and fulfilled the age criterion of 89 years or older for males and 91 years or older for females, representing less than 0.5% of the Dutch population in 2001 (Schoenmaker et al 2006, doi: [10.1038/sj.ejhg.5201508](http://https://www.nature.com/articles/5201508); Westendorp et al 2009, doi: [10.1111/j.1532-5415.2009.02381.x](http://https://agsjournals.onlinelibrary.wiley.com/doi/10.1111/j.1532-5415.2009.02381.x)). In total 944 long-lived siblings were included with a mean age of 94 years (range 89-104), 1671 offspring (61 years, 34-81) and 744 partners (60 years, 30-79). It is family based study consists of 1671 offspring of 421 nonagenarians sibling pairs of Dutch descent, and their 744 partners. Of all LLS participants HRC1.1 imputed genotypes are available.
- Start Year
- 2002
| Investigators | Contacts |
|---|---|
|
Design
- Study design
- Cohort
Recruitment
- Sources of Recruitment
-
- Individuals
- Families
Number of participants
- Number of participants
- 3,359
- Number of participants with biosamples
- 3,359
Access
Available on request
| Data | |
| Biosamples | |
| Imaging |
Timeline
Populations
Nonagerians siblings
Selection Criteria
- Minimum age
-
89
- Newborns
- Twins
- Countries
-
- Netherlands
- Health Status
-
Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
-
- Other specific population : Long lived siblings
Number of participants
- Number of participants
- 944
- Number of participants with biosamples
- 944
Data Collection Event
For the Leiden Longevity Study, long-lived siblings of European descent were recruited together with their offspring and the partners of the offspring between 2002 and 2006. Families were recruited if at least two long-lived siblings were alive and fulfilled the age criterion of 89 years or older for males and 91 years or older for females, representing less than 0.5% of the Dutch population in 2001 (Schoenmaker et al 2006, doi: 10.1038/sj.ejhg.5201508; Westendorp et al 2009, doi: 10.1111/j.1532-5415.2009.02381.x). In total 944 long-lived siblings were included with a mean age of 94 years (range 89-104), 1671 offspring (61 years, 34-81) and 744 partners (60 years, 30-79). It is family based study consists of 1671 offspring of 421 nonagenarians sibling pairs of Dutch descent, and their 744 partners. The dataset of the LLS IOP1 Nonagenarian Siblings consists of 944 long-lived siblings from 421 families of whom we have biosamples, biomarkers, and questionnaire data. We followed these nonagenarian participants for their vital status till 2020.
- Start Date
-
2002-07
- End Date
-
2006-02
- Data sources
-
- Physical measures
- Biosamples
- Biomarkers
- Questionnaires
- Data sources - Biosamples
-
- Blood
- Buccal cells
Partner offspring
Selection Criteria
- Newborns
- Twins
- Countries
-
- Netherlands
- Health Status
-
Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
-
- Other specific population : Offspring of nonagenarian siblings and partners thereof
Number of participants
- Number of participants
- 2,415
- Number of participants with biosamples
- 2,415
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
IOP1_Partoffs
|
For the Leiden Longevity Study, long-lived siblings of European descent were recruited together with their offspring and the partners of the offspring between 2002 and 2006. Families were ... | 2002-09 | 2006-05 |
| 1 |
IOP2_Partoffs
|
From the group of 2,415 LLS PartnerOffspring that participated in the LLS between 2002 and 2006, 686 participants were examined for the second time between 2006 and 2008. In total 343 offspring ... | 2006-10 | 2008-03 |
| 2 |
IOP3_Partoffs
|
From the group of 343 couples (Ntotal=686_ LLS PartnerOffspring that participated in the LLS between 2006 and 2008, 500 participants were examined for the third time between 2009 and 2010. In ... | 2009-08 | 2010-12 |
| 3 |
LLS Questionnaire 1
|
2006-02 | 2008-05 | |
| 4 |
LLS Follow Up study
|
2021-11 | 2023-09 |